Gastro- Retentive floating tablets: A promising strategy for improving dapsone therapeutic efficacy.

This review explores the formulation and development of floating tablets for gastro-retentive drug delivery systems (GRDDS), focusing on their ability to prolong gastric retention and enhance the therapeutic efficacy of drugs with narrow absorption windows. The article discusses key components of floating tablet systems, mechanisms of buoyancy, materials, methods, and evaluation parameters. The significance of such systems for improving therapeutic outcomes and patient compliance is highlighted, along with the limitations and challenges faced in formulation.Dapsone is a widely used antimicrobial agent, suffers from limitations such as poor solubility, short gastric residence time, and variable bioavailability, leading to suboptimal therapeutic outcomes. Gastro-retentive drug delivery systems (GRDDS), particularly floating tablets, offer a promising approach to overcoming these challenges by prolonging gastric retention and enhancing drug absorption. This review explores the formulation strategies, mechanisms, and advantages of gastroretentive floating tablets for Dapsone. Key aspects such as polymer selection, effervescent and noneffervescent floating mechanisms, pharmacokinetic benefits, and in vitro/in vivo evaluation methods are discussed. Additionally, formulation challenges and future prospects, including the potential for advanced polymer technologies and nanocarriers, are highlighted. By improving gastric retention and controlled drug release, floating tablets could significantly enhance the therapeutic efficacy of Dapsone, making them a promising alternative to conventional oral dosage forms.