Formulation and Evaluation of Paracetamol Ip 75 Mg Immediate Release Tablet

The aim of the present study was to formulate and develop an immediate release (IR) tablet of paracetamol at a low dose of 75 mg, suitable for paediatric or low-dose adult applications. Paracetamol, a widely used analgesic and antipyretic, requires prompt onset of action, making rapid disintegration and dissolution crucial for therapeutic effectiveness. The formulation was designed using direct compression and wet granulation techniques with various combinations of excipients including microcrystalline cellulose, Binders, and super disintegrant such as croscarmellose sodium. Tablets were evaluated for pre-compression and post-compression parameters including hardness, friability, weight variation, disintegration time, and in vitro drug release profile. The optimized formulation exhibited rapid disintegration within 5 min and released more than 85% of the drug, complying with pharmacopeial specifications for immediate release dosage forms. The study successfully demonstrates that a 75 mg paracetamol IR tablet can be effectively formulated using standard excipients and techniques, providing a reliable low-dose option with fast therapeutic action