Formulation Development and characterization of Quercetin Loaded Nanoemulsion

The major limitations of quercetin delivery, including solubility and bioavailability, can be effectively overcome by encapsulating it into a precise nanoemulsion system. Optimized quercetinloaded nanoemulsion exhibited improved solubility, permeability, biocompatibility, oral bioavailability, and stability with multifaceted therapeutic applications. Applications for quercetin have been restricted because of its weak water solubility and high sensitivity to chemical degradation. In order to use quercetin as a functional food component, this study assessed the hypocholesterolemic activity of quercetin and quercetin-loaded nanoemulsion (NQ) and examined the effects of pH on the production of NQ. The NQ particle size ranged from 207 to 289 nm, with a polydispersity index of less than 0.47. As the pH rose from 4.0 to 9.0, the encapsulation effectiveness gradually improved from 56 to 92%. During three months of storage at 21 and 37 °C, NQ demonstrated good stability in the pH range of 6.5 to 9.0.