Skin microbiome analysis of a junctional epidermolysis bullosa patient treated with genetically modified stem cells
Our investigation confirms a unique microbiome composition in JEB, characterized by S. aureus driven bacterial overgrowth. The dysbiosis was not reversed in transgenic, non-blistering skin areas. However, the transgenic skin demonstrates stability in an environment of bacterial dysbiosis.
Authors
- Claudia Traidl‐Hoffmann (ORCID: https://orcid.org/0000-0001-5085-5179)
- Claudia Hülpüsch (ORCID: https://orcid.org/0000-0002-5711-1356)
- Avidan U. Neumann (ORCID: https://orcid.org/0000-0002-2149-5917)
- Tobias Hirsch (ORCID: https://orcid.org/0000-0002-3641-2707)
- Alexander Dermietzel
- Matthias Reiger (ORCID: https://orcid.org/0000-0002-6173-2104)
- Luise Rauer (ORCID: https://orcid.org/0000-0001-7970-2678)
- Kai J. Wessel
- Minh-Tri Nguyen
- Maximilian Kueckelhaus
- Burcu Tosun
Institutions
- University of Augsburg (DE)
- Helmholtz Zentrum München (DE)
- Augenstern (DE)
- University Hospital Münster (DE)
- CK-CARE (CH)
- Fachklinik Hornheide (DE)
- Agaplesion Diakonieklinikum Rotenburg (DE)
Publication Details
- Journal
- JDDG Journal der Deutschen Dermatologischen Gesellschaft
- Published
- 2025-06-12
- DOI
- https://doi.org/10.1111/ddg.15776
- Primary Topic
- Skin and Cellular Biology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00