Tibial Mechanoadaptation in Male Mice is Modularised and Retained in Aging
We conclude that load-induced cortical responses are partially retained, whereas trabecular bone appears resistant to loading in males of all ages. These data indicate modular patterns of mechanoadaptation across bone compartments that align with the emergence of age-related skeletal frailty.
Authors
- Andrew A. Pitsillides (ORCID: https://orcid.org/0000-0002-3861-998X)
- Roberto Lopes de Souza (ORCID: https://orcid.org/0000-0002-8079-7181)
- Samuel Monzem (ORCID: https://orcid.org/0000-0002-8600-4875)
Institutions
- Florida Institute of Technology (US)
- Royal Veterinary College (GB)
- Universidade Federal de Mato Grosso (BR)
Publication Details
- Journal
- Journal of Bone Metabolism
- Published
- 2025-05-31
- DOI
- https://doi.org/10.11005/jbm.24.817
- Primary Topic
- Bone health and osteoporosis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- LifeArc
- Medical Research Council