Analytical Method Development and Validation for Estimation of Tamsulosin Hydrochloride by UV-Spectroscopic Method

Tamsulosin Hydrochloride is a medication primarily used in men to treat the symptoms of an enlarged prostate, also known as benign prostatic hyperplasia (BPH). It belongs to a class of drugs called alpha – blocker. A simple, specific, rapid, precise and accurate UV Spectroscopic method have been developed and validated for determination of Tamsulosin Hydrochloride. Drug showed the absorption maxima at 280 nm and was linear for a range of 10 – 50 µg/ml with a correlation coefficient 0f 0. 9944.The validation of the above proposed method was done by carrying out precision and accuracy studies. The percentage recovery at three different levels i.e. 80%, 100% and 120% was found to be 99.8%, 99.9% and 99.9% respectively. The analytical method showed good Intra precision (repeatability) with relative standard deviation 1.445% and Inter precision with relative standard deviation is 1.939% which is less than 2. The proposed method was validated for the parameter Precision, Linearity and range, Accuracy, Robustness, Ruggedness, LOD, and LOQ. Hence proposed analytical method for estimation of Tamsulosin Hydrochloride formulation drug by UV spectrophotometer in pharmaceutical can be applied for the routine quality control analysis.