Formulation and Evaluation of Medicated Lotion for Treatment of Rosacea

:Rosacea is a chronic dermatological condition characterized by persistent erythema, pustules, and inflammation, which disrupts skin homeostasis and exacerbates vascular and immune responses. Chronic inflammation in rosacea leads to increased vascular permeability, immune dysregulation, and oxidative stress, contributing to skin barrier dysfunction and persistent flare-ups. This study focuses on formulating and evaluating a medicated lotion containing metronidazole and niacinamide, two active ingredients known for their anti-inflammatory, antimicrobial, and skin-soothing properties. The formulation is designed to target inflammatory pathways while ensuring compatibility with sensitive skin. A comprehensive evaluation, including physicochemical characterization, stability testing, and both in vitro and in vivo studies, was conducted to assess its therapeutic potential. Results demonstrated a significant reduction in redness and inflammation, enhanced skin hydration, and improved barrier function, with excellent tolerability and minimal adverse effects. This research underscores the importance of targeted topical formulations in controlling inflammation-driven skin damage, paving the way for further optimization and largescale clinical studies for rosacea management.