Prevalence of <i>Salmonella enterica</i> Serotype 4,[5],12:i:- from Human Sources: Antimicrobial Resistance, Genotypic Diversity and Emergence of Carbapenem Resistance — China, 2017–2023

<i>Salmonella</i> 4,[5],12:i:- is highly sporadic in China but remains phylogenetically linked to the prevalent MDR clone with a distinct resistance profile worldwide. The emergence of elevated resistance to third-generation cephalosporins and sharp rise in carbapenem resistance, coupled with the detection of plasmid-mediated resistance determinants, suggests the evolution of endemic MDR clones circulating within China. These findings emphasize the need for enhanced surveillance, stricter regulations on antibiotic use in agriculture, comprehensive risk factor surveys, and targeted interventions to prevent outbreaks.