Defining early vascular aging in youth: an expert consensus document from the youth vascular consortium
The concept of early vascular aging (EVA) was introduced to identify adults at risk of developing premature cardiovascular disease. EVA, or the dissociation between chronologic and biologic age of large arteries, is an evolving concept. In this review, we propose that EVA in youth characterizes the early life biological and environmental risk factors that precede overt EVA. During early infancy, childhood and/or adolescence, structural and/or functional characteristics of the macrovascular and/or microvascular system may deviate from that expected for the chronological age of the individual. Assessing vascular aging from a young age may help detect and prevent the early onset of cardiovascular disease. This consensus document from the Youth Vascular Consortium outlines the principles of EVA in youth (birth to 24 years), examines factors influencing vascular growth, and identifies current knowledge gaps. It also provides an expert consensus on defining EVA in youth. Supplementary Tables 1-3, http://links.lww.com/HJH/C733 , http://links.lww.com/HJH/C734 , http://links.lww.com/HJH/C735 supply key references for risk factors associated with EVA at different points in development; 1. Neonates to childhood; 2. Adolescence; 3. Young adults. Supplementary Table 4, http://links.lww.com/HJH/C736 displays reference ranges of EVA in adults.
Authors
- Vikas R. Dharnidharka (ORCID: https://orcid.org/0000-0001-8000-1385)
- Yolandi Breet (ORCID: https://orcid.org/0000-0001-5067-8387)
- Manish D. Sinha (ORCID: https://orcid.org/0000-0001-7593-1203)
- Ruan Kruger (ORCID: https://orcid.org/0000-0001-7680-2032)
- Daniel Bia (ORCID: https://orcid.org/0000-0001-7160-7166)
- Wayne Smith (ORCID: https://orcid.org/0000-0002-7101-7331)
- Lee Stoner (ORCID: https://orcid.org/0000-0002-0682-2270)
- Peter M. Nilsson (ORCID: https://orcid.org/0000-0002-5652-8459)
- Keeron J. Stone (ORCID: https://orcid.org/0000-0001-6572-7874)
- Anuradha Vaman Khadilkar (ORCID: https://orcid.org/0000-0002-3399-3235)
- Rosa María Bruno (ORCID: https://orcid.org/0000-0002-6107-3356)
- Henner Hanssen (ORCID: https://orcid.org/0000-0001-5501-4205)
- Rachel E. Climie (ORCID: https://orcid.org/0000-0002-7960-360X)
- Erzsébet Valéria Hidvégi (ORCID: https://orcid.org/0000-0003-4113-2395)
- Elaine M. Urbina (ORCID: https://orcid.org/0000-0002-5640-6777)
- Madeleine Johansson (ORCID: https://orcid.org/0000-0001-9057-9148)
- Michél Strauss‐Kruger (ORCID: https://orcid.org/0000-0003-0619-4654)
- Yanina Zócalo (ORCID: https://orcid.org/0000-0002-6544-2518)
- Mieczysław Litwin (ORCID: https://orcid.org/0000-0002-5241-2483)
- Catharina M. C. Mels (ORCID: https://orcid.org/0000-0003-0138-3341)
- Vimarsha Kodithuwakku (ORCID: https://orcid.org/0000-0002-0657-3251)
- Giacomo Pucci
- Alejandro Díaz (ORCID: https://orcid.org/0000-0001-7536-3269)
- Daniel James Cuthbertson (ORCID: https://orcid.org/0000-0002-6128-0822)
- Karsten Königstein (ORCID: https://orcid.org/0000-0002-2994-8570)
- Jeanne Hersant (ORCID: https://orcid.org/0000-0002-7126-0534)
Institutions
- University of North Carolina at Chapel Hill (US)
- Cincinnati Children's Hospital Medical Center (US)
- University of Tasmania (AU)
- St. Louis Children's Hospital (US)
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Inserm (FR)
- Universidad de la República de Uruguay (UY)
- King's College London (GB)
- University of Basel (CH)
- Lund University (SE)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Université Paris Cité (FR)
- University of Szeged (HU)
- University of Perugia (IT)
- North-West University (ZA)
- Jehangir Hospital (IN)
- Universidad Nacional del Centro de la Provincia de Buenos Aires (AR)
- British Heart Foundation (GB)
- Children's Memorial Health Institute (PL)
- Comisión Sectorial de Investigación Científica (UY)
- Paris Cardiovascular Research Center (FR)
- Skåne University Hospital (SE)
- Evelina London Children's Healthcare (GB)
- ASM Terni (Italy) (IT)
- NIHR Research Delivery Network (GB)
- Université d'Angers (FR)
- University of Cincinnati (US)
- University of Pecs (HU)
- Cardiff Metropolitan University (GB)
Publication Details
- Journal
- Journal of Hypertension
- Published
- 2025-05-21
- DOI
- https://doi.org/10.1097/hjh.0000000000004056
- Citations
- 5
- Primary Topic
- Cardiovascular Health and Disease Prevention
- Type
- article
- Field-Weighted Citation Impact
- 6.94