Quantifying mitochondrial viscosity changes by an AIE probe during drug therapy
A novel viscosity-sensitive, mitochondrial-targeted AIE fluorescent probe, TPE-4TPP, was developed to quantify dynamic changes in mitochondrial viscosity induced by an anticancer drug. Using fluorescence lifetime as a bridge, a quantitative relationship between drug duration and mitochondrial viscosity was established.
Authors
- Yujun Feng (ORCID: https://orcid.org/0000-0001-5046-6085)
- Yueyao Liu
- Jinghui Qiao
- Zhigui Ma (ORCID: https://orcid.org/0000-0003-2966-361X)
- Xuezhi Zhao
Institutions
- Sichuan University (CN)
- West China Second University Hospital of Sichuan University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc01021g
- Citations
- 2
- Primary Topic
- Molecular Sensors and Ion Detection
- Type
- article
- Field-Weighted Citation Impact
- 1.51
Funders
- National Natural Science Foundation of China
- State Key Laboratory of Polymer Materials Engineering