Formulation and Evaluation of Floating Microspheres of Losartan Potassium Using Sodium Alginate and Gum Acacia

This research aimed to prepare gastroretentive floating microsphere of antihypertensive drug. Nine batches of gum acacia alginate-based microspheres of Losartan Potassium were formulated by ionic gelation technique, each having 50mg drug strength. (F1 - F9)Compatibility studies confirmed no interaction between drug & excipients. Prepared microspheres were evaluated for physicochemical characteristics, entrapment efficiency, mucoadhesion potential and in vitro drug release potential. The drug loading (%) and entrapment efficiency (%) was calculated and it was observed that entrapment efficiency ranges from 67.85% to 96.88%. Batch F5 having maximum entrapment efficiency of 96.88% and in this batch Sodium Alginate & Gum Acacia are present in the ratio of 0.5:1. Results of in vitro drug release of batch F5 was compared with release of pure drug and it was found that pure drug showed 99.56% release in 3hours and batch F5 showed 98.54% release in 24 hours. Batch F5 showed very good stability profile as well. It was observed that the formulated microspheres of Losartan Potassium (F5) were superior, economic and effective in achieving patient compliance