Formulation, Optimization, and Evaluation of a Polyherbal AntiOxidant Lotion Incorporating Psidium guajava and Moringa oleifera Leaf Extracts

The increasing demand for natural skincare products has led to the development of a polyherbal antioxidant lotion incorporating Psidium guajava (guava) and Moringa oleifera (moringa) leaf extracts. Both plants are known for their potent antioxidant properties, due to their high levels of flavonoids, phenolics, and vitamins. The extracts were prepared through cold maceration and tested for antioxidant activity, demonstrating significant free radical scavenging potential. Different formulations of the lotion were developed using different concentrations of the extracts and evaluated for key physicochemical parameters, including pH, viscosity, spreadability, and texture. The optimized formulation exhibited a pH range of 5.8–6.5, smooth texture, and ideal viscosity for easy application. Stability testing over 30 days under various temperature conditions (4°C, 25°C, and 40°C) showed no signs of phase separation or instability. The optimized formulation demonstrated high antioxidant activity, confirming the synergistic effects of Psidium guajava and Moringa oleifera extracts. The emulsion was characterized as oil-inwater (O/W), promoting skin hydration without greasiness. Microbial testing confirmed the absence of harmful microorganisms, ensuring the lotion’s safety for use. A skin irritation test conducted on human volunteers showed no signs of redness, itching, or irritation, indicating excellent dermatological compatibility. This polyherbal antioxidant lotion is a promising natural skincare product, offering protection from oxidative stress and contributing to skin health. Further clinical studies are recommended to explore its long-term efficacy and commercial viability