One-Pot Regioselective Functionalization of Quinone Imine Ketals: Direct Access to <i>ortho</i>-Substituted Anilines from Arylamines

Herein, we have demonstrated an acid-catalyzed reaction that selectively performs the <i>ortho</i>-functionalization of anilines in a nondirected one-pot procedure. In addition to dramatically simplifying the synthesis of <i>ortho</i>-substituted anilines, our approach has the advantage of the scalability and remarkable regioselectivity, including product derivatization. The control experiments provide insight into the reaction mechanism and the origin of <i>ortho</i>-selectivity.