A multi-omics and mediation-based genetic screening approach identifies STX4 as a key link between epigenetic regulation, immune cells, and childhood asthma
This study systematically identifies and validates STX4 as a key genetic regulator in childhood asthma by integrating large-scale genetic, epigenetic, and immune regulatory data. These findings provide strong evidence for STX4's role in childhood asthma pathogenesis, highlighting STX4 as a potential target for future precision therapies in childhood asthma.
Authors
- Xiaochen Du (ORCID: https://orcid.org/0000-0003-1204-2665)
- Hongying Wang (ORCID: https://orcid.org/0000-0003-4814-8816)
- Yuan Zhang (ORCID: https://orcid.org/0000-0002-4630-0450)
- Jun Hua
- Lijun Zhou (ORCID: https://orcid.org/0000-0003-2636-0541)
- Yujuan Yang (ORCID: https://orcid.org/0000-0003-4635-2709)
- Yaqiong Ren
Institutions
- Soochow University (CN)
- Wujiang District People's Hospital (CN)
- Children's Hospital of Suzhou University (CN)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1186/s13148-025-01908-x
- Citations
- 2
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- Science and Technology Program of Suzhou