Abstract P2-01-15: Survivorship attributes in women with hormone receptor positive breast cancer at long term follow-up in the CLEAR Study of Late Recurrence

Abstract Background: Limited data are available on long-term breast cancer (BC) survivorship. We examined this issue in women with hormone receptor positive BC recruited at least 4 years post-diagnosis onto a prospective cohort study that investigates survivorship as well as host and circulating factors associated with risks of late recurrence. Methods: At study entry (2019-2022), 423 women provided information regarding overall health, marital status, current living situation, vitamin/supplement/alternative therapy use, participation in supportive activities. They also completed the Attachment subscale of the Social Provisions Scale and the Holmes and Rahe Stress Scale. Results: Mean age was 61.4 ± 9.8 years, 93.6% were post-menopausal. 322 (76.1%) identified as white, 16 (3.8%) black, 70 (16.5%) Asian, and Latin America/Hispanic 9 (2.1%). Mean time from surgery to enrolment 7.5 ± 2.8 years, mean CTS5 score 4.2 ± 0.6 % per year. 100 (23.6%) tumors were HER2+, 368 (87%) received chemotherapy. 274 (64.8%) were still on endocrine therapy (ET): 194 (45.9%) on AIs and 80 (18.9%) on tamoxifen at the time of enrolment. Mean duration of ET 6.5 ± 2.4 years. Mean BMI was 27.3 ± 5.9 kg/m2: 25.8% obese, 34.3% overweight, 38.5% normal weight. 213 (50.4%) consumed alcohol in the last year, mean 5 ± 4.3 drinks per week. 377 (89.1%) used dietary supplements: 328 (77.5%) vitamin D, 93 (22.0%) multivitamins, 80 (18.9%) vitamin C and 172 (40.7%) calcium, 66 (15.6%) reported using alternative supplements, notably cranberry and Coenzyme Q10. 276 (65.2%) were married, 65 (15.4%) separated/divorced, 35 (8.3%) widowed, 47(11.1%) never married. Most lived with a partner 279 (66%); 59 (13.9%) with other family members or friends and 82 (19.4%) lived alone. Overall health during the past year was considered stable or better by 306 (84.2%) subjects. 266 (62.9%) reported engaging in at least 1 of the following supportive activities therapy, meditation, yoga, and group exercise. Mean score on the Attachment subscale of the Social Provisions Scale was 15 + 1.7 (range 0 to 16); 254 (60%) reported the maximum score, indicating excellent close attachment and support. In contrast, 154 (36.4%) scored in the highest risk category (>300) on the Stress Scale. The most frequently endorsed items were changes in family get togethers, social activities, vacations, health of family members and work conditions, likely reflecting the COVID pandemic. Conclusions: In the CLEAR study, with a mean of 7.5 years post-diagnosis, BC survivors reported strong support, with strong emotional ties and stable overall health. However, they experienced high stress and high alcohol consumption, possibly related to the COVID pandemic. Further analysis addressing diet, physical activity and medical status, and change over time are ongoing. Citation Format: Ana Elisa Lohmann, Marguerite Ennis, David W Cescon, Stephen K Chia, Christine Brezden-Masley, Christine Elser, Kamran Fazaee, Carol Townsley, Katarzyna Jerzak, Pamela J Goodwin. Survivorship attributes in women with hormone receptor positive breast cancer at long term follow-up in the CLEAR Study of Late Recurrence [abstract]. In: Proceedings of the San Antonio Breast Cancer Symposium 2024; 2024 Dec 10-13; San Antonio, TX. Philadelphia (PA): AACR; Clin Cancer Res 2025;31(12 Suppl):Abstract nr P2-01-15.