Abstract P5-10-19: Impact of Online Case-Based Education in Improving Clinicians’ Knowledge and Confidence in Managing HER2-Low Metastatic Breast Cancer

Abstract Background: HER2-low breast cancer has generated great interest recently due to the introduction of novel antibody-drug conjugate (ADC) therapy into the clinical practice and the remarkable outcomes it has achieved. The objective of this study was to assess the effect of an online case-based continuing medical education (CME) activity on clinicians’ knowledge of the available evidence supporting the use of novel ADC therapy for patients with HER2-low metastatic breast cancer and their confidence in individualizing treatment plans for those patients. Methods: This 18-minute segmented multi-media online CME activity consisted of videos portraying realistic physician–patient interaction followed by a test question and expert commentary. Educational effect was assessed using a repeated-pair design with pre-/post-assessment. 3 multiple choice questions assessed knowledge, and 1 question rated on a Likert-type scale assessed confidence, with each individual serving as their own control. A McNemar’s test assessed significance of improvement in the percentage of correct responses to knowledge questions from pre- to post-assessment. P values < .05 are statistically significant. The activity launched on 28th of August, 2023, with data collected through 29th December, 2023 being reported in the current study. Results: 63 oncologists and 36 obstetricians/gynaecologists who answered all the assessment questions were included in this analysis. Analysis of pre- vs post-intervention responses demonstrated a significant improvement in overall knowledge of both physician learner groups, with 200% more oncologists answering all questions correctly after education (30% post- vs 10% pre-CME) and 113% more obstetricians/gynaecologists answering all questions correctly after education (17% post- vs 8% pre-CME). Specifically, the knowledge regarding the latest clinical data in HER2-low breast cancer increased from 45% pre- to 65% post-CME for oncologists (P<.001) and from 33% pre- to 48% post-CME (P<.01) for obstetricians/gynaecologists, respectively. Additionally, 41% of oncologists and 31% of obstetricians/gynaecologists reported increased confidence in individualizing treatment plans for patients with HER2-low metastatic breast cancer, and that increase was, on average, 71% and 52% among the two physician groups, respectively. Conclusions: This analysis demonstrates the success of online, interactive, case-based education in improving clinician’s knowledge and confidence in managing patients with HER2-low metastatic breast cancer. However, there remains a need to provide ongoing education to clinicians in this growing field. Citation Format: Zhizhi Fiske, Stephen Dunn, Deborah Grainger, Jamie Habib, Judy King. Impact of Online Case-Based Education in Improving Clinicians’ Knowledge and Confidence in Managing HER2-Low Metastatic Breast Cancer [abstract]. In: Proceedings of the San Antonio Breast Cancer Symposium 2024; 2024 Dec 10-13; San Antonio, TX. Philadelphia (PA): AACR; Clin Cancer Res 2025;31(12 Suppl):Abstract nr P5-10-19.