Interleukin-1β in circulating mononuclear cells predicts steatotic liver disease improvement after weight loss in subjects with obesity and prediabetes or type 2 diabetes
In patients with obesity with initial impairment of glucose metabolism successful weight loss is associated with a reduction of both IL-1β levels and MASLD degree. Of interest, basal levels of IL-1β predict the extent of MASLD improvement, regardless of the intervention. Our results may set the stage for ad-hoc studies investigating the usefulness of baseline IL-1β a level as a drug-response biomarker.
Authors
- Agostino Consoli (ORCID: https://orcid.org/0000-0002-1885-451X)
- Paola Simeone (ORCID: https://orcid.org/0000-0002-8057-1975)
- Francesco Cipollone (ORCID: https://orcid.org/0000-0002-5993-9341)
- Rossella Liani (ORCID: https://orcid.org/0000-0002-1523-530X)
- Augusto Di Castelnuovo (ORCID: https://orcid.org/0000-0001-9767-7998)
- Sarah Costantino (ORCID: https://orcid.org/0000-0002-3003-7213)
- Alessandro Mengozzi (ORCID: https://orcid.org/0000-0003-2834-9725)
- Francesco Paneni (ORCID: https://orcid.org/0000-0001-6483-7844)
- Romina Tripaldi
- Francesco Cosentino (ORCID: https://orcid.org/0000-0002-6967-5685)
- Armando Tartaro (ORCID: https://orcid.org/0000-0003-0095-2792)
- Francesca Santilli (ORCID: https://orcid.org/0000-0002-4593-905X)
Institutions
- University of Pisa (IT)
- Karolinska University Hospital (SE)
- University of Zurich (CH)
- Karolinska Institutet (SE)
- Istituto Neurologico Mediterraneo (IT)
- University of Chieti-Pescara (IT)
- University Hospital of Zurich (CH)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1186/s12933-025-02706-8
- Citations
- 4
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.42