Rapid and Slow Progressors Toward β-Cell Depletion and Their Predictors in Type 1 Diabetes: Prospective Longitudinal Study in Japanese Type 1 Diabetes (TIDE-J)
This study elucidates the heterogeneity in β-cell dysfunction among Japanese individuals with type 1 diabetes and identifies genetic and clinical predictors of disease progression. These findings provide insights for individualized management strategies and future therapeutic interventions.
Authors
- Shinsuke Noso (ORCID: https://orcid.org/0000-0002-0943-8450)
- Kan Nagasawa
- Akihisa Imagawa (ORCID: https://orcid.org/0000-0002-4213-3229)
- Daisuke Chujo (ORCID: https://orcid.org/0000-0001-7727-6310)
- Kyoichiro Tsuchiya (ORCID: https://orcid.org/0000-0002-2863-4561)
- Takuya Awata (ORCID: https://orcid.org/0000-0003-2622-8129)
- Tetsuro Tsujimoto (ORCID: https://orcid.org/0000-0002-0230-1718)
- Takeshi Katsuki (ORCID: https://orcid.org/0000-0002-4355-0446)
- Haruhiko Osawa (ORCID: https://orcid.org/0000-0003-0289-8363)
- Noriko Kodani (ORCID: https://orcid.org/0000-0002-4443-1545)
- Eiryo Kawakami (ORCID: https://orcid.org/0000-0001-9955-4342)
- Yoichi Oikawa (ORCID: https://orcid.org/0000-0003-1524-6751)
- Norikazu Maeda (ORCID: https://orcid.org/0000-0002-7105-0836)
- Tomoyasu Fukui (ORCID: https://orcid.org/0000-0002-8535-008X)
- Eiji Kawasaki (ORCID: https://orcid.org/0000-0001-7434-4744)
- Masayuki Shimoda (ORCID: https://orcid.org/0000-0002-0338-0008)
- Akira Shimada (ORCID: https://orcid.org/0000-0002-3954-4983)
- Hisafumi Yasuda (ORCID: https://orcid.org/0000-0003-3742-9268)
- Hiroshi Kajio (ORCID: https://orcid.org/0000-0002-5404-651X)
- Tetsuro Kobayashi (ORCID: https://orcid.org/0000-0002-4364-2527)
- Ichiro Horie (ORCID: https://orcid.org/0000-0003-3430-5796)
- Junji Kozawa (ORCID: https://orcid.org/0000-0001-9665-8947)
- Junnosuke Miura (ORCID: https://orcid.org/0000-0002-5115-1111)
- Hiroshi Ikegami (ORCID: https://orcid.org/0000-0001-8808-4605)
- Kazuki Yasuda (ORCID: https://orcid.org/0000-0002-6966-496X)
- Norio Abiru
- Kazuma Takahashi
- Yasumichi Mori
- Masato Kasuga
Institutions
- Hyogo University of Health Sciences (JP)
- SHOWA Medical University (JP)
- University of Nagasaki (JP)
- Iwate Medical University (JP)
- Kyorin University (JP)
- National Center for Global Health and Medicine (JP)
- Sakai Municipal Hospital (JP)
- University of Yamanashi Hospital (JP)
- Koga Hospital (JP)
- Saiseikai Central Hospital (JP)
- The Cancer Institute Hospital (JP)
- Okinaka Memorial Adult Disease Research Institute (JP)
- Ehime University (JP)
- Nagasaki University (JP)
- Iwate Prefectural University (JP)
- Kobe University (JP)
- International University of Health and Welfare (JP)
- Saitama Medical University (JP)
- Osaka University of Pharmaceutical Sciences (JP)
- Kindai University (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Diabetes Care
- Published
- 2025-06-13
- DOI
- https://doi.org/10.2337/dc25-0579
- Citations
- 2
- Primary Topic
- Diabetes Management and Research
- Type
- article
- Field-Weighted Citation Impact
- 2.59
Funders
- Merck KGaA
- Taiho Pharmaceutical
- Kindai University
- National Center for Global Health and Medicine
- Kanazawa University
- Novo Nordisk
- Ono Pharmaceutical
- Novo Nordisk Pharma