Enhanced HIV-1 Neutralizing Antibody Breadth in HTLV-2 Co-Infected Individuals: Influence of Antiretroviral Regimen and B Cell Subset Distribution
Co-infection with HTLV-2 enhances bNAb production in PWH on suppressive ART and, in particular, in the absence of r-PI regimens. The prominent neutralizing activity corresponded with B cell subset distributions. The results suggest the complexity regarding the interaction between viral co-infections, antiretroviral regimens, and humoral immune compartments and may inform further H1V-1 pathogenesis inquiries or the appropriate design of a vaccine.
Authors
- Víctor Sánchez-Merino (ORCID: https://orcid.org/0000-0001-9400-427X)
- Eloísa Yuste (ORCID: https://orcid.org/0000-0002-9484-9974)
- Ana Isabel Parro‐Moreno (ORCID: https://orcid.org/0000-0002-9712-950X)
- María Jesús Vivancos (ORCID: https://orcid.org/0000-0002-9373-6011)
- Alejandro Vallejo (ORCID: https://orcid.org/0000-0001-5360-878X)
- Marı́a Jesús Pérez-Elı́as (ORCID: https://orcid.org/0000-0001-5700-5257)
- María J. Ruiz-de-León
- José L. Casado (ORCID: https://orcid.org/0000-0002-7639-8591)
- Carmen Quereda
- Fernando Dronda
Institutions
- Instituto Cajal (ES)
- Instituto de Salud Carlos III (ES)
- Centro de Investigación Biomédica en Red (ES)
Publication Details
- Journal
- Vaccines
- Published
- 2025-06-13
- DOI
- https://doi.org/10.3390/vaccines13060639
- Primary Topic
- T-cell and Retrovirus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00