Abstract PS10-07: The Molecular Subtypes of Breast Cancer: A Single Institution Experience after a Decade of the Syrian War

Abstract Background: Breast cancer is the most commonly diagnosed type of cancer and the leading cause of cancer-related death among women. Breast cancer mortality rates in Syria rank among the highest in the world. There are few studies about breast cancer epidemiology or patient characteristics in Syria. This study aimed to evaluate estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expression in Syrian patients with breast cancer. Methods: This retrospective study included all new patients with a confirmed diagnosis of breast cancer via biopsy in 2023. The data were retrieved from the Albairouni University Hospital (ABUH) cancer registry. Results: 1460 patients were included in the study. BC is the most commonly diagnosed cancer in ABUH (21.6%). The patients were distributed among the majority of hormonal receptors (HR)+/HER2- (711, 48.7%), followed by HR+/HER2+ (327, 22.4%), followed by HR-/HER2+ (271, 18.6%) and HR-/HER2- (151, 10.3%). Conclusion: More than 50% of breast cancer cases in Syria are HER2+ and triple-negative, which may indicate a poor prognosis. Syrian healthcare practices, including cancer registry practices, were negatively impacted by a decade-long war. Data collection regarding other pathological findings, patients' characteristics, and clinical outcomes is still in progress. Citation Format: Maher Saifo. The Molecular Subtypes of Breast Cancer: A Single Institution Experience after a Decade of the Syrian War [abstract]. In: Proceedings of the San Antonio Breast Cancer Symposium 2024; 2024 Dec 10-13; San Antonio, TX. Philadelphia (PA): AACR; Clin Cancer Res 2025;31(12 Suppl):Abstract nr PS10-07.