Catalyst-free efficient synthesis of functionalized 1,2,4-triazole <i>via</i> ring opening/cyclization of arylidene thiazolone with aryl/alkyl-hydrazine
We report a catalyst-free synthesis of hydrazone-substituted 1,2,4-triazoles <i>via</i> ring opening/intramolecular cyclization of arylidene thiazolone by aryl/alkyl-hydrazine. The reaction exhibits a broad substrate scope and is demonstrated on a gram scale in both batch and continuous flow synthesis. Furthermore, the direct one-pot synthesis of indole-substituted 1,2,4-triazole expands its structural diversity.
Authors
- Anshul Jain (ORCID: https://orcid.org/0000-0003-1647-5142)
- Akanksha Kumari (ORCID: https://orcid.org/0000-0003-2531-2329)
- Sermadurai Selvakumar (ORCID: https://orcid.org/0000-0001-9069-9174)
- Nirmal K. Rana (ORCID: https://orcid.org/0000-0001-9224-2725)
- Himani Sharma (ORCID: https://orcid.org/0000-0003-1924-6222)
Institutions
- Indian Institute of Technology Jodhpur (IN)
- Indian Institute of Technology Indore (IN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc02145f
- Citations
- 2
- Primary Topic
- Click Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Science and Engineering Research Board