The effect of sodium‐glucose cotransporter 2 inhibitors on <scp>HbA1c</scp> variability and cardiovascular and renal adverse outcome in patients with <scp>T2DM</scp>
In patients with high HbA1c variability, SGLT2 inhibitor initiation was associated with superior effectiveness in reducing HbA1c variability compared to DPP-4 inhibitors. The initiation of SGLT2 inhibitors versus DPP-4 inhibitors was linked to significantly reduced cardiovascular and renal adverse events.
Authors
- Christopher Tze‐Wei Tsang (ORCID: https://orcid.org/0000-0003-3394-6604)
- Ran Guo (ORCID: https://orcid.org/0000-0003-0654-6314)
- Mei‐Zhen Wu
- J.-R. Zhang
- Haochen Xuan (ORCID: https://orcid.org/0000-0002-2017-9285)
- Yingxian Liu (ORCID: https://orcid.org/0000-0003-1155-7130)
- Q W Ren (ORCID: https://orcid.org/0000-0003-0712-9299)
- Wouter Ouwerkerk (ORCID: https://orcid.org/0000-0002-2000-9358)
- Chanchal Chandramouli (ORCID: https://orcid.org/0000-0001-8256-902X)
- Carolyn S.P. Lam (ORCID: https://orcid.org/0000-0003-1903-0018)
- Jasper Tromp (ORCID: https://orcid.org/0000-0001-6043-0713)
- Wenli Gu (ORCID: https://orcid.org/0000-0001-7162-6017)
- Tiew‐Hwa Katherine Teng (ORCID: https://orcid.org/0000-0002-8431-9961)
- Jiayi Huang (ORCID: https://orcid.org/0000-0002-5153-506X)
- Anping Cai (ORCID: https://orcid.org/0000-0002-5587-5811)
- Kai‐Hang Yiu
- Yik‐Ming Hung
- Ambarish Pandey
- Ching‐Yan Zhu
Institutions
- University Medical Center Groningen (NL)
- National University of Singapore (SG)
- University of Groningen (NL)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Queen Mary Hospital (CN)
- Peking Union Medical College Hospital (CN)
- Baim Institute for Clinical Research (US)
- Guangzhou First People's Hospital (CN)
- University of Hong Kong - Shenzhen Hospital (CN)
- Guangdong Academy of Medical Sciences (CN)
- National Heart Centre Singapore (SG)
- National University Health System (SG)
- Amsterdam University Medical Centers (NL)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
- The University of Texas Southwestern Medical Center (US)
- University of Amsterdam (NL)
- University of Hong Kong (HK)
- South China University of Technology (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1111/dom.16509
- Citations
- 3
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 3.88
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Hospital Authority
- Sanming Project of Medicine in Shenzhen