Primary splenic non-germinal center B-cell large lymphoma with associated granulomatous inflammation: A rare presentation

Introduction: Granulomatous inflammation has been reported in association with both Hodgkin and non- Hodgkin lymphomas. Its presence alongside lymphoma is uncommon and may complicate the diagnostic process. Case Report: We report the case of a 72-year-old male who presented to our hospital with weight loss, night sweats, and general deterioration. His medical history included urothelial carcinoma treated with Bacillus Calmette–Guérin (BCG) therapy in 2020. Clinical examination revealed splenomegaly extending to the flank. An excisional splenic biopsy confirmed the diagnosis of diffuse large B-cell lymphoma (DLBCL) with associated granulomatous inflammation. Conclusion: This case illustrates an atypical presentation of DLBCL with granulomatous inflammation, emphasizing the need for careful histopathological assessment in such scenarios.