Abstract P5-02-06: Investigating the Impact of a Culturally Tailored Education Intervention Cancer Clinical Trial Participation

Abstract Background: Cancer clinical trials (CCT) advance knowledge in cancer care. Access to CCT may be facilitated by patient knowledge. We evaluated the impact of a culturally tailored CCT educational video intervention via a pre- and post-test survey on CCT interest and knowledge dissemination. Methods: A CCT education intervention was developed with community engagement from persons who identified as Black, Hispanic, or Chinese, the predominant background of persons in our immediate catchment area. The video educational intervention was available in Spanish and Chinese. Community input was to make the survey available prior to the diagnosis of cancer; therefore, participants included a general population (GP), persons who did not have a cancer diagnosis. Pre and post knowledge assessments were utilized to evaluate knowledge (11 questions) and intention-to-share information/participate in a CCT (6 questions) using a Fisher-exact test. Data were analyzed after stratifying by race. Results: The sample size included: 148 (70%) men, 58 (28%) women, 2 (1%) transgender, 2 (1%) non-binary; white, non-Latinx 125 (60%), Black 60 (29%), Asian 2 (1%), Latinx 52 (25%). Significant findings included, for Black participants, the score for the question "Once I sign a consent form, I must stay in the clinical trial until my doctor tells me I'm done" improved significantly between pre- and post-intervention (p=0.0104). For white, non-Latinx participants, CCT knowledge improved for the following questions "Once I sign a consent form, I must stay in the clinical trial until my doctor tells me I'm done." (p = 0.0181), "Clinical trials of new medicines or treatments are carefully reviewed for safety by a group of research experts and community members." (p = 0.0314) and "You can only join a clinical trial after you have tried all other options." (p = 0.0316). The intention to gain more information about CT from their physicians and discussing CT with family (p<0.05) improved significantly in all groups. Conclusion: A tailored educational intervention significantly knowledge based questions and impacted the intention to learn more about CCT and to share the CCT information learned. Citation Format: Jesutomisola Onafowokan, Nikita Nikita, Iqra Siddiqui, Ana María López. Investigating the Impact of a Culturally Tailored Education Intervention Cancer Clinical Trial Participation [abstract]. In: Proceedings of the San Antonio Breast Cancer Symposium 2024; 2024 Dec 10-13; San Antonio, TX. Philadelphia (PA): AACR; Clin Cancer Res 2025;31(12 Suppl):Abstract nr P5-02-06.