Storage duration of packed red blood cells transfused during veno-venous extracorporeal membrane oxygenation is associated with elevated pulmonary artery pressure and lung injury in a sheep model
Transfusion of stored RBC elevated pulmonary artery pressure when compared to fresh RBC transfusion and controls. This change was correlated with a greater post-transfusion lung injury in the stored RBC group. Further investigation assessing whether insufficient nitric oxide had a role in these findings is warranted, as is consideration of longer ECMO durations and greater transfusion volumes.
Authors
- Sara Diab (ORCID: https://orcid.org/0000-0003-4743-6787)
- Charles McDonald (ORCID: https://orcid.org/0000-0003-3667-7892)
- Kiran Shekar (ORCID: https://orcid.org/0000-0002-1239-7514)
- Margaret R. Passmore (ORCID: https://orcid.org/0000-0002-0859-8882)
- S. R. Foley (ORCID: https://orcid.org/0000-0002-9346-7456)
- Gabriela Šimonová (ORCID: https://orcid.org/0000-0002-3012-6611)
- John‐Paul Tung (ORCID: https://orcid.org/0000-0001-7210-0527)
- Yoke Lin Fung (ORCID: https://orcid.org/0000-0002-7777-6179)
- Fergal T. Temple (ORCID: https://orcid.org/0000-0003-0497-2694)
- John F. Fraser
- Kimble R. Dunster
Institutions
- Queensland University of Technology (AU)
- The University of Queensland (AU)
- University of the Sunshine Coast (AU)
- Australian Red Cross Lifeblood (AU)
- Prince Charles Hospital (AU)
- Children's Health Queensland Hospital and Health Service (AU)
Publication Details
- Journal
- Critical Care
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1186/s13054-025-05438-z
- Primary Topic
- Mechanical Circulatory Support Devices
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Australian Government
- Medical Research Council
- National Health and Medical Research Council