Gambogic acid suppresses osteosarcoma progression through upregulation of FOXO3a
The findings suggest that GA exerts potent anticancer effects on osteosarcoma cells through the upregulation of FOXO3a, a critical tumor suppressor. These results provide a foundation for further exploration of GA as a novel therapeutic agent for osteosarcoma, potentially offering a safer alternative to conventional chemotherapy. Future research will aim to elucidate the detailed mechanisms underlying the interaction between GA and FOXO3a and to optimize GA-based therapeutic strategies.
Authors
- Yawei Hu (ORCID: https://orcid.org/0000-0002-5993-6765)
- Jiawen Wu (ORCID: https://orcid.org/0000-0002-6286-5937)
- Zengfeng Guo
- Hao Zhang (ORCID: https://orcid.org/0000-0002-1437-9918)
- Xiaohong Han
- Jianhua Zhou (ORCID: https://orcid.org/0000-0001-8609-7111)
- Songqing Ye
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Shenzhen Bao'an District People's Hospital (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1007/s12672-025-02776-w
- Citations
- 1
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Guangzhou Medical University