Hederagenin promotes <i>SIRT6</i> to attenuate epidural scar formation by aggravating PRMT1 deacetylation
Generally, the therapeutic role of HE treatment on epidural scar formation was exerted by regulating <i>SIRT6</i>/<i>PRMT1</i> axis-mediated ER stress and RANKL pathway. This study provides evidence of a novel therapeutic measure for epidural scar formation.
Authors
- Xiaochen Fan (ORCID: https://orcid.org/0000-0002-4316-0616)
- Jue Wang (ORCID: https://orcid.org/0000-0001-9227-6589)
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Xi'an Honghui Hospital (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Bone and Joint Research
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1302/2046-3758.146.bjr-2024-0287.r2
- Citations
- 1
- Primary Topic
- Macrophage Migration Inhibitory Factor
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- National Natural Science Foundation of China
- Yakult Bio-Science Foundation
- Key Research and Development Projects of Shaanxi Province