Association of HER2-low with clinicopathological features in patients with early invasive lobular breast cancer: an international multicentric study
HER2-low is present in more than half of the patients with early ER+ HER2- pure ILCs and is associated with larger tumor size and multifocality. HER2-low is associated with a worse DFS and OS as compared to HER2 0.
Authors
- Ha-Linh Nguyen (ORCID: https://orcid.org/0000-0002-2538-7657)
- Ann Smeets (ORCID: https://orcid.org/0000-0002-5091-6602)
- Patrick Neven (ORCID: https://orcid.org/0000-0002-1434-9460)
- Marion Maetens (ORCID: https://orcid.org/0000-0002-0505-2622)
- Ines Nevelsteen (ORCID: https://orcid.org/0000-0003-4380-7413)
- Denis Larsimont (ORCID: https://orcid.org/0000-0003-2152-253X)
- Peter Vermeulen (ORCID: https://orcid.org/0000-0002-5676-3141)
- Guilherme Nader Marta (ORCID: https://orcid.org/0000-0001-7864-3637)
- François Richard (ORCID: https://orcid.org/0000-0003-4353-3619)
- Elia Mario Biganzoli (ORCID: https://orcid.org/0000-0003-1202-5873)
- Christine Desmedt (ORCID: https://orcid.org/0000-0002-5223-5579)
- Hans Wildiers (ORCID: https://orcid.org/0000-0001-8990-7837)
- Karen Van Baelen (ORCID: https://orcid.org/0000-0002-5700-3574)
- Gitte Zels (ORCID: https://orcid.org/0000-0002-6332-3830)
- Maria Margarete Karsten (ORCID: https://orcid.org/0000-0001-7587-7550)
- Giuseppe Floris (ORCID: https://orcid.org/0000-0003-2391-5425)
- Adam David Dordevic (ORCID: https://orcid.org/0000-0003-3839-807X)
- Luc Dirix (ORCID: https://orcid.org/0000-0002-6248-1677)
- Evandro de Azambuja (ORCID: https://orcid.org/0000-0001-9501-4509)
Institutions
- Université Libre de Bruxelles (BE)
- University of Milan (IT)
- Breast Cancer Research Foundation (US)
- Institut Jules Bordet (BE)
- VIB-KU Leuven Center for Cancer Biology (BE)
- Ziekenhuisnetwerk Antwerpen Stuivenberg (BE)
- Charité - Universitätsmedizin Berlin (DE)
- UCLouvain (BE)
- KU Leuven (BE)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1186/s13058-025-02058-x
- Citations
- 1
- Primary Topic
- HER2/EGFR in Cancer Research
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Conquer Cancer Foundation
- Breast Cancer Alliance
- Fonds Wetenschappelijk Onderzoek
- KU Leuven
- Vlaamse regering