HSP Inhibitor Sensitize Resistant MCF-7 Cells to Doxorubicin through SuppressingHSP90AB4P Pseudogene and HSPB1 Expression
Our findings demonstrate that 7A suppresses doxorubicin resistance in MCF-7/ADR cells by reducing the expression of HSP90AB4P and small HSPB1, leading to an increase in apoptosis and cell cycle arrest. The combination of 7A and doxorubicin exhibits a synergistic effect (CI < 1), enhancing cytotoxicity and overcoming resistance mechanisms. The cells are driven to apoptosis and the inhibitor significantly decreases doxorubicin resistance. Targeting HSPB1 and its pseudogene HSP90AB4P with 7A offers a promising therapeutic strategy to overcome doxorubicin resistance in breast cancer.
Authors
- Ali Çelik (ORCID: https://orcid.org/0000-0001-5385-6492)
- Kübra Açıkalın Coşkun (ORCID: https://orcid.org/0000-0002-0047-8368)
- Elif Cansu Abay
- Yusuf Tutar (ORCID: https://orcid.org/0000-0003-2613-9644)
- İrfan Koca (ORCID: https://orcid.org/0000-0001-7873-159X)
- Levent Gülüm
- Mehmet Gümüş (ORCID: https://orcid.org/0000-0003-1240-8284)
- Lütfi Tutar
Institutions
- Recep Tayyip Erdoğan University (TR)
- Istanbul Aydın University (TR)
- Akdeniz University (TR)
- Ahi Evran University (TR)
- Yozgat Bozok Üniversitesi (TR)
- Technologies pour la Santé (FR)
- Sağlık Bilimleri Üniversitesi (TR)
- Institute of Occupational Safety (SI)
- Istanbul University (TR)
- Bolu Abant İzzet Baysal University (TR)
Publication Details
- Journal
- Anti-Cancer Agents in Medicinal Chemistry
- Published
- 2025-06-11
- DOI
- https://doi.org/10.2174/0118715206374072250530103333
- Citations
- 2
- Primary Topic
- Heat shock proteins research
- Type
- article
- Field-Weighted Citation Impact
- 1.61