Expression of PIM1/ASK1 Molecular Pathway Related Genes in Ischemic Cardiomyopathy
In conclusion, ICM patients have altered ASK1 expression compared to NF individuals. The significant down-regulation of ASK1 and JAK1, along with the up-regulation of STAT5B and NF-κB, suggests that targeting ASK1 could be an important strategy to ameliorate ischemia-related cardiomyocyte damage.
Authors
- Seyed‐Mohamad‐Sadegh Mirahmadi (ORCID: https://orcid.org/0000-0003-0664-2031)
- Hamidreza Pazoki–Toroudi (ORCID: https://orcid.org/0000-0001-7868-456X)
- Seyed Ahmad Hosseini (ORCID: https://orcid.org/0000-0002-8404-0039)
- Mohammad Pirhayati (ORCID: https://orcid.org/0000-0002-2619-3731)
- Navid Farahmandian (ORCID: https://orcid.org/0000-0002-4596-7157)
- Mohammadjavad Sotoudeheian (ORCID: https://orcid.org/0000-0001-7181-2944)
- Reza Azarbad (ORCID: https://orcid.org/0000-0002-8238-5404)
Institutions
- Iran University of Medical Sciences (IR)
- Babol University of Medical Sciences (IR)
Publication Details
- Journal
- Cardiovascular & Haematological Disorders - Drug Targets
- Published
- 2025-06-13
- DOI
- https://doi.org/10.2174/011871529x366280250526131550
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00