Autoantibody clusters in rheumatoid arthritis are not driven by antigen specificity or isotype
Autoantibody clusters are most likely not driven by AMPA specificity or isotype profile, neither before nor at RA onset, but are instead determined by a broad variety of autoantibodies. This indicates that the triggers for autoantibody development in RA do not skew the response towards certain autoreactivities or isotypes but rather lead to a broad and diverse autoantibody repertoire reflecting continuous and ongoing immune activation.
Authors
- Linda Johansson (ORCID: https://orcid.org/0000-0001-7071-4699)
- Diane van der Woude (ORCID: https://orcid.org/0000-0001-8121-5879)
- Rachel Knevel (ORCID: https://orcid.org/0000-0002-7494-3023)
- Heidi Kokkonen (ORCID: https://orcid.org/0000-0001-9600-5364)
- René E. M. Toes (ORCID: https://orcid.org/0000-0002-9618-6414)
- M. Maurits (ORCID: https://orcid.org/0000-0002-3266-6232)
- Solbritt Rantapää‐Dahlqvist (ORCID: https://orcid.org/0000-0001-8259-3863)
- Tineke J van Wesemael (ORCID: https://orcid.org/0000-0002-3101-0530)
- Anouk G. van Mourik (ORCID: https://orcid.org/0000-0002-3811-7373)
- Johan Rönnelid (ORCID: https://orcid.org/0000-0003-1186-3226)
Institutions
- Uppsala University (SE)
- Leiden University Medical Center (NL)
- Umeå University (SE)
Publication Details
- Journal
- RMD Open
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1136/rmdopen-2024-005291
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- ZonMw