Microsampling with dried blood spots and mass spectrometry enables PK/PD profiling of responses to praziquantel in a Schistosoma haematobium–exposed Zimbabwean population
We show that low-cost microsampling using DBS and MS is feasible for detecting and quantifying PZQ and its metabolites. Furthermore, our pharmacogenetics analysis elucidates the impact of known cytochrome P450 variants on PZQ drug response in an African setting.
Authors
- Grace Zdesenko (ORCID: https://orcid.org/0000-0002-0012-3436)
- Francisca Mutapi (ORCID: https://orcid.org/0000-0002-2537-3466)
- Gavin J. Blackburn (ORCID: https://orcid.org/0000-0003-1037-6012)
- Richard Burchmore (ORCID: https://orcid.org/0000-0003-1663-9004)
- Takafira Mduluza (ORCID: https://orcid.org/0000-0002-5613-5014)
- David Twesigomwe (ORCID: https://orcid.org/0000-0002-5421-5512)
Institutions
- Andrews University (US)
- University of Zimbabwe (ZW)
- University of the Witwatersrand (ZA)
- Western General Hospital (GB)
- Institute of Immunology (HR)
- Institute of Genetics and Cancer (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- Pharmacogenetics and Genomics
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1097/fpc.0000000000000572
- Primary Topic
- Parasites and Host Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00