Association of VKORC1 and CYP2C9 gene polymorphisms with warfarin dose requirements in a representative Iranian population with cardiac valve replacement surgery
The CYP2C9 rs1057910 variant was significantly associated with daily warfarin dose requirements, suggesting its potential role in guiding idividualized dosing. In contrast, VKORC1 rs2884737 showed no significant association in this population, despite previous findings in other ethnic groups.
Authors
- Javad Gharechahi (ORCID: https://orcid.org/0000-0001-7018-4085)
- Omid Maleki
Institutions
- Baqiyatallah University of Medical Sciences (IR)
Publication Details
- Journal
- Pharmacogenetics and Genomics
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1097/fpc.0000000000000571
- Primary Topic
- Pharmacogenetics and Drug Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00