Endothelial CHOP as a central mechanism in renovascular hypertension-induced vascular endothelial dysfunction and cardiac fibrosis
Our research findings determined that CHOP is a central mechanism driving vascular endothelial dysfunction and cardiac fibrosis in renovascular hypertension. Therefore, targeting CHOP in endothelial cells could be a potential therapeutic approach to protect against the pathogenesis of renovascular hypertension.
Authors
- Khalid Matrougui (ORCID: https://orcid.org/0000-0001-9269-2937)
- Hamid Suhail
- Maurizio Rizzi
- Paula Fortuno
- B. Srinivas
- Krishnam Raju Alluri
- Nour‐Eddine Rhaleb
Institutions
- Henry Ford Health System (US)
- Wayne State University (US)
- Henry Ford Hospital (US)
- Department of Physiological Sciences (RU)
Publication Details
- Journal
- Cellular and Molecular Life Sciences
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1007/s00018-025-05741-6
- Citations
- 4
- Primary Topic
- Renal and Vascular Pathologies
- Type
- article
- Field-Weighted Citation Impact
- 6.07
Funders
- National Institutes of Health