Multi-level regulation of hindgut homeostasis by volatile fatty acid administration in dairy goats: linking microbial metabolism to epithelial inflammation and barrier function
The volatile fatty acids (VFAs), mainly produced by rumen microbiota, play an important role in ruminal metabolic functions and epithelial health, but their impact on the hindgut has received limited attention. Our study highlighted the significant role of VFAs in hindgut bacterial metabolism and homeostasis, providing novel insights into the role of VFAs in regulating hindgut metabolism and physiological homeostasis beyond the rumen.
Authors
- Yuhong Zhong (ORCID: https://orcid.org/0000-0001-6204-5827)
- Jianjun Ma (ORCID: https://orcid.org/0009-0006-2036-3986)
- Jiaqi Lin
- Yongkang Zhen (ORCID: https://orcid.org/0000-0002-6979-4633)
- Mengzhi Wang (ORCID: https://orcid.org/0000-0002-6256-8166)
- Chong Zhang (ORCID: https://orcid.org/0000-0001-9609-8855)
- Rahmat Ali (ORCID: https://orcid.org/0000-0003-4145-3332)
Institutions
- Xinjiang Academy of Agricultural and Reclamation Science (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- mSystems
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1128/msystems.00116-25
- Citations
- 4
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- National Natural Science Foundation of China
- Priority Academic Program Development of Jiangsu Higher Education Institutions