Limosilactobacillus reuteri SXDT-32-derived shikimic acid protects against colonic inflammation in piglets by inhibiting the PI3K-Akt pathway
L. reuteri SXDT-32 alleviated intestinal inflammation in piglets by producing SA that inhibits the PI3K-Akt pathway. This study provides an innovative approach for the treatment and prevention of colitis caused by bacterial infection.
Authors
- Liang Chen (ORCID: https://orcid.org/0000-0002-5706-6559)
- Ruqing Zhong (ORCID: https://orcid.org/0000-0003-0494-6699)
- Qingshi Meng (ORCID: https://orcid.org/0000-0002-1074-8405)
- Zhenzhen Zhan (ORCID: https://orcid.org/0000-0002-4943-1659)
- Shuo Liu (ORCID: https://orcid.org/0000-0001-7580-7675)
- Ruixiao Mao
- Chengzeng Luo (ORCID: https://orcid.org/0000-0002-3284-6049)
- X.X. Zhang
- Shunfen Zhang (ORCID: https://orcid.org/0000-0003-4895-9299)
- Ying Chen (ORCID: https://orcid.org/0009-0005-8351-6620)
- Hongfu Zhang (ORCID: https://orcid.org/0000-0001-6915-660X)
- Chunran Teng
Institutions
- Shanxi Agricultural University (CN)
- Qingdao Agricultural University (CN)
- Chinese Academy of Agricultural Sciences (CN)
- Institute of Animal Sciences (CN)
Publication Details
- Journal
- Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1186/s40104-025-01221-w
- Citations
- 1
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Agricultural Science and Technology Innovation Program