Heparin-Binding Protein as a Diagnostic Biomarker for Healthcare-Associated Meningitis and Ventriculitis in Pediatric Patients

CSF HBP is a more accurate candidate biomarker superior to lactate and PCT for diagnosing healthcare-associated meningitis and ventriculitis among pediatric patients. Early HBP analysis of CSF in suspected patients may facilitate early detection of CSF infections.

Authors

Guangzhi Shi (ORCID: https://orcid.org/0000-0003-4189-5800)
Yueyue Kong (ORCID: https://orcid.org/0009-0000-4983-3175)
Yongji Tian (ORCID: https://orcid.org/0000-0001-9915-8630)
Zhiming Liu (ORCID: https://orcid.org/0000-0002-4030-862X)
Jiahao Niu

Institutions

Capital Medical University (CN)
Peking University (CN)
Beijing Jishuitan Hospital (CN)
Beijing Tian Tan Hospital (CN)
Beijing Institute of Neurosurgery (CN)

Publication Details

Journal: Neurosurgery
Published: 2025-06-13
DOI: https://doi.org/10.1227/neu.0000000000003505
Primary Topic: Bacterial Infections and Vaccines
Type: article
Field-Weighted Citation Impact: 0.00

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article

Heparin-Binding Protein as a Diagnostic Biomarker for Healthcare-Associated Meningitis and Ventriculitis in Pediatric Patients

Guangzhi Shi, Yueyue Kong, Yongji Tian, Zhiming Liu et al.

Jun 13, 2025

Neurosurgery

Bacterial Infections and Vaccines

article

Heparin-Binding Protein as a Diagnostic Biomarker for Healthcare-Associated Meningitis and Ventriculitis in Pediatric Patients

Guangzhi Shi, Yueyue Kong, Yongji Tian, Zhiming Liu, Jiahao Niu

June 13, 2025article en

Abstract

CSF HBP is a more accurate candidate biomarker superior to lactate and PCT for diagnosing healthcare-associated meningitis and ventriculitis among pediatric patients. Early HBP analysis of CSF in suspected patients may facilitate early detection of CSF infections.

NeurosurgeryVol. 97(3)

Capital Medical University (CN), Peking University (CN), Beijing Jishuitan Hospital (CN), Beijing Tian Tan Hospital (CN), Beijing Institute of Neurosurgery (CN)

Openalex Percentile: Top 87%

Bacterial Infections and Vaccines

DOI Source OpenAlex

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Heparin-Binding Protein as a Diagnostic Biomarker for Healthcare-Associated Meningitis and Ventriculitis in Pediatric Patients — Guangzhi Shi, Yueyue Kong, et al. · Neurosurgery (2025) | TGRS Research Map | TGRS