Ubiquitin-specific protease 38 modulates atrial fibrillation susceptibility in chronic kidney disease via STRAP stabilization and activation of TGF-β/SMAD signaling
USP38 is a critical mediator of CKD-associated AF, promoting atrial fibrosis and electrical remodeling via STRAP stabilization and TGF-β/SMAD pathway activation. Targeting USP38 may represent a novel therapeutic strategy for CKD-associated AF.
Authors
- Hong Meng (ORCID: https://orcid.org/0000-0002-3746-0997)
- He Huang
- Zheng Xiao
- Bin Kong (ORCID: https://orcid.org/0000-0002-0951-0416)
- Wei Shuai (ORCID: https://orcid.org/0000-0002-5507-7369)
- Hongjie Yang
- Zongze Qu
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1186/s10020-025-01296-1
- Citations
- 6
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 8.33