Simple Practical Preparations of Sufentanil from Cheap and Commercially Available 1-methyl-4-piperidone
Novel simple approach was elaborated for the preparation of fentanyl and sufentanil starting from commercially available, cheap 1-methyl-4-piperidone. Compared to existing syntheses new route is shorter, easily scalable, and does not require the use of expensive palladium catalysts, highpressure equipment, and chromatographic separations. Moreover, it allows for to avoidance of working with the unstable norsufentanil, which is prone to a facile acyl migration to the nitrogen atom of the piperidine core even at ambient temperature, resulting in contamination of the target product.
Authors
- A. G. Buyanovskaya (ORCID: https://orcid.org/0000-0003-4963-3979)
- O. S. Shilova
- Sergey K. Moiseev (ORCID: https://orcid.org/0000-0002-9104-8725)
- Sofia M. Morozova (ORCID: https://orcid.org/0000-0001-8680-3653)
- Valentine G. Nenajdenko (ORCID: https://orcid.org/0000-0001-9162-5169)
- А. B. Koldobskii
Institutions
- Moscow Institute of Physics and Technology (RU)
- Moscow Power Engineering Institute (RU)
- Bauman Moscow State Technical University (RU)
- Lomonosov Moscow State University (RU)
- A. N. Nesmeyanov Institute of Organoelement Compounds (RU)
Publication Details
- Journal
- Letters in Organic Chemistry
- Published
- 2025-06-13
- DOI
- https://doi.org/10.2174/0115701786366473250601080424
- Primary Topic
- Analytical Methods in Pharmaceuticals
- Type
- article
- Field-Weighted Citation Impact
- 0.00