Molecular characterization and resistance mechanisms of ertapenem-non-susceptible carbapenem-resistant <i>Klebsiella pneumoniae</i> co-harboring ESBLs or AmpC enzymes with porin loss or efflux pump overexpression
This study highlights the complex, multifactorial nature of carbapenem resistance in carbapenem-resistant <i>Klebsiella pneumoniae</i> (CRKP), involving enzyme-mediated resistance, reduced membrane porin expression, and overactive efflux pumps. These findings provide valuable insights into CRKP resistance mechanisms and can aid in controlling CRKP in China.
Authors
- Lingyue Meng (ORCID: https://orcid.org/0009-0009-5196-8234)
- Taijie Li
- Jingru Bi
- Guangmei Zou
- Xin Huang
- Yingying Su
- Wei Zhao (ORCID: https://orcid.org/0000-0002-7155-6108)
Institutions
- Guangxi Medical University (CN)
- Yulin University (CN)
Publication Details
- Journal
- Journal of Bacteriology
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1128/jb.00148-25
- Citations
- 6
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 3.55
Funders
- Natural Science Foundation of Guangxi Zhuang Autonomous Region
- Guangxi Traditional Chinese Medical University