Biomimetic Synthesis of Myrtucommulones D–E
A concise and efficient biomimetic synthesis of myrtucommulones D-E has been achieved, proceeding in just 6-7 linear steps from readily available biogenetic building blocks. The key feature of the synthesis was the Zn-mediated skeletal rearrangement reaction, without the need for rare metal photocatalysts and visible light. Based on this biomimetic synthesis, four compounds demonstrated moderate to excellent cytotoxic activities against osteosarcoma cells (U2OS and 143B).
Authors
- Yanxia Hu (ORCID: https://orcid.org/0000-0002-1815-6324)
- Meiqi Zheng
- Min-Jing Cheng (ORCID: https://orcid.org/0009-0008-0072-7433)
- Wen‐Cai Ye (ORCID: https://orcid.org/0000-0002-2810-1001)
- Shi-Lin Lin
- Chuang‐Chuang Li (ORCID: https://orcid.org/0000-0003-4344-0498)
- Y. F. Zhu (ORCID: https://orcid.org/0000-0002-7791-5650)
- Lei Wang (ORCID: https://orcid.org/0000-0001-9242-1109)
- Sisi Wang (ORCID: https://orcid.org/0000-0001-7156-8486)
- Ming-Fang Qi
- Hong Min Guo (ORCID: https://orcid.org/0000-0002-0999-684X)
- Yan-Yi Wu
Institutions
- Southern University of Science and Technology (CN)
- Guangdong-Hongkong-Macau Joint Laboratory of Collaborative Innovation for Environmental Quality (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1021/acs.joc.5c00859
- Citations
- 3
- Primary Topic
- Synthesis of Organic Compounds
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- National Natural Science Foundation of China