Live <i>Malassezia</i> strains from the mucosa of patients with ulcerative colitis: pathogenic potential and environmental adaptations

<i>Malassezia</i> fungi predominantly reside on human skin and are associated with several skin diseases, such as seborrheic dermatitis. They have also been implicated in various other diseases, including inflammatory bowel disease (IBD). While <i>Malassezia</i> DNA has been detected in many fungal microbiome studies using fecal samples, no previous research had isolated live <i>Malassezia</i> strains from the gut or confirmed that live <i>Malassezia</i> cells reside within the gut environment. In this study, we successfully isolated live <i>Malassezia globosa</i> strains from the gut mucosal surface of ulcerative colitis patients and compared them to <i>M. globosa</i> skin isolates. Our results revealed significant differences in pathogenicity between the gut and skin isolates and suggest the important role of <i>M. globosa</i> in the gut and its involvement in IBD.

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Publication Details

Journal
mBio
Published
2025-06-13
DOI
https://doi.org/10.1128/mbio.01400-25
Citations
2
Primary Topic
Bee Products Chemical Analysis
Type
article
Field-Weighted Citation Impact
3.34

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article

Live Malassezia strains from the mucosa of patients with ulcerative colitis: pathogenic potential and environmental adaptations

Minji Park, David M. Underhill, Won Hee Jung, Chul‐Su Yang et al.
2 citations
mBio
Bee Products Chemical Analysis
3.34
article

Live Malassezia strains from the mucosa of patients with ulcerative colitis: pathogenic potential and environmental adaptations

Minji Park, David M. Underhill, Won Hee Jung, Chul‐Su Yang, Yong‐Joon Cho, Chang Hwan Choi, Muhyeon Sung, Piyapat Rintarhat, Juan Yang, Dong‐Woo Lee, Seung Yong Shin, Kate Lagree, Sohyeong Choi, Hyo Keun Kim
article en
2 citations

Abstract

<i>Malassezia</i> fungi predominantly reside on human skin and are associated with several skin diseases, such as seborrheic dermatitis. They have also been implicated in various other diseases, including inflammatory bowel disease (IBD). While <i>Malassezia</i> DNA has been detected in many fungal microbiome studies using fecal samples, no previous research had isolated live <i>Malassezia</i> strains from the gut or confirmed that live <i>Malassezia</i> cells reside within the gut environment. In this study, we successfully isolated live <i>Malassezia globosa</i> strains from the gut mucosal surface of ulcerative colitis patients and compared them to <i>M. globosa</i> skin isolates. Our results revealed significant differences in pathogenicity between the gut and skin isolates and suggest the important role of <i>M. globosa</i> in the gut and its involvement in IBD.

mBioVol. 16(7)
Cedars-Sinai Medical Center (US), University of California, Los Angeles (US), Kangwon National University (KR), Yonsei University (KR), Hanyang University (KR), Chung-Ang University (KR), Anyang University (KR)
National Research Foundation of Korea, Korea National Institute of Health
Openalex Percentile: Top 9%
Bee Products Chemical Analysis
3.34
DOIOpen Access PDFOpenAlex
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