Germline–Somatic Liaison Dictates Cancer Subtypes via <i>de novo</i> Steroid Biosynthesis
Significant heritability is observed for common cancer types worldwide. The molecular mechanisms by which inherited genetics facilitate cancer initiation might transit through its cooperation with specific somatic events that then dictate the tumor features. Through a germline-somatic tandem leading to steroid biosynthesis, we suggest a paradigm to study cancer initiation.
Authors
- Francesco Orlando (ORCID: https://orcid.org/0000-0001-9884-9413)
- Yari Ciani (ORCID: https://orcid.org/0000-0002-9635-2830)
- Wilbert Zwart (ORCID: https://orcid.org/0000-0002-9823-7289)
- Giulia Fracassi (ORCID: https://orcid.org/0000-0002-1947-6637)
- Sebastian Gregoricchio (ORCID: https://orcid.org/0000-0001-9209-5403)
- Christopher E. Barbieri (ORCID: https://orcid.org/0000-0002-0381-1947)
- Antonio Casini (ORCID: https://orcid.org/0000-0001-7709-4955)
- Nima Sharifi (ORCID: https://orcid.org/0000-0003-1281-3474)
- Paola Gasperini (ORCID: https://orcid.org/0000-0002-3016-9742)
- Yoon‐Mi Chung (ORCID: https://orcid.org/0000-0001-9721-9444)
- Gianluca Petris (ORCID: https://orcid.org/0000-0002-2420-6359)
- Andrea Lunardi (ORCID: https://orcid.org/0000-0001-6218-2565)
- Francesca Lorenzin
- Orsetta Quaini (ORCID: https://orcid.org/0009-0008-3466-8988)
- Alessandro Alaimo (ORCID: https://orcid.org/0000-0002-5888-6268)
- Francesca Demichelis (ORCID: https://orcid.org/0000-0002-8266-8631)
- Yanis Zekri (ORCID: https://orcid.org/0000-0003-4925-4610)
- Blerta Stringa (ORCID: https://orcid.org/0000-0002-2902-5979)
- Anna Cereseto (ORCID: https://orcid.org/0000-0003-4453-2597)
Institutions
- University of Udine (IT)
- NewYork–Presbyterian Hospital (US)
- University of Trento (IT)
- Washington University in St. Louis (US)
- Cornell University (US)
- New York Hospital Queens (US)
- Lander Institute (IL)
- Fondazione Italiana Fegato (IT)
- Presbyterian Hospital (US)
- University of Miami Health System (US)
- Netherlands Heart Institute (NL)
- Oncode Institute (NL)
- Sylvester Comprehensive Cancer Center (US)
- Trento RISE (Italy) (IT)
- Eindhoven University of Technology (NL)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1158/2159-8290.cd-24-1904
- Primary Topic
- Nutrition, Genetics, and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00