Novel insights into beta cell ER stress CHOP and its role in HFpEF development
Our research indicates that deleting the unfolded protein response CHOP in b-cells has a robust cardiovascular protective effect against HFpEF pathogenesis. Therefore, targeting CHOP in b-cells is a promising lead for HFpEF pathogenesis therapy.
Authors
- Hamid Suhail
- Balaji Srinivas
- Hongmei Peng (ORCID: https://orcid.org/0000-0001-7214-5995)
- Hani N. Sabbah (ORCID: https://orcid.org/0000-0002-2850-6105)
- Paula Fortuno
- Jiang Xu
- Khalid Matrougui
- Nour‐Eddine Rhaleb
Institutions
- Henry Ford Health System (US)
- Wayne State University (US)
- Henry Ford Hospital (US)
- Old Dominion University (US)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1186/s12933-025-02703-x
- Citations
- 5
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 10.03
Funders
- National Institutes of Health