Effect of hormone therapy on tryptophan metabolism and atherosclerosis among postmenopausal women
Plasma tryptophan-kynurenine pathway metabolites were reduced by HT and these reduced metabolite levels were associated with decreased atherosclerosis progression. Reduction of kynurenic acid by HT was supported by its association with E2 levels, which may explain, in part, the reduction in atherosclerosis progression with HT in early postmenopausal women.
Authors
- Wendy Jean Mack (ORCID: https://orcid.org/0000-0002-2474-7921)
- James R. Hilser (ORCID: https://orcid.org/0000-0001-5849-7839)
- Roksana Karim (ORCID: https://orcid.org/0000-0003-1761-153X)
- Intira Sriprasert (ORCID: https://orcid.org/0000-0001-5367-762X)
- Naoko Kono
- Frank Z. Stanczyk (ORCID: https://orcid.org/0000-0002-3607-121X)
- Donna Shoupe
- Hooman Allayee (ORCID: https://orcid.org/0000-0002-2384-5239)
- Howard N. Hodis
Institutions
- University of Southern California (US)
Publication Details
- Journal
- Climacteric
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1080/13697137.2025.2509838
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00