GFH018 and Toripalimab Combination Therapy for Previously Treated Recurrent or Metastatic Nasopharyngeal Carcinoma: Results from a Phase Ib/II Study
The combination of GFH018 and toripalimab showed a manageable toxicity profile and durable antitumor activity in patients with R/M NPC, especially those without prior ICI exposure.
Authors
- Sai-Lan Liu (ORCID: https://orcid.org/0009-0007-4965-9526)
- Muh‐Hwa Yang (ORCID: https://orcid.org/0000-0002-8918-1244)
- Hai‐Qiang Mai (ORCID: https://orcid.org/0000-0001-6735-8670)
- Xiaozhong Chen (ORCID: https://orcid.org/0009-0009-6877-9042)
- Mun N. Hui (ORCID: https://orcid.org/0000-0003-3238-0119)
- Ye Guo (ORCID: https://orcid.org/0000-0002-1813-9815)
- Yujuan Zhou (ORCID: https://orcid.org/0000-0002-5195-8724)
- Lin‐Quan Tang (ORCID: https://orcid.org/0000-0002-9613-7305)
- Hua-Qiang Zhu
- Hanjie Shen (ORCID: https://orcid.org/0009-0000-9271-6812)
- Hui‐Ching Wang (ORCID: https://orcid.org/0000-0002-8232-0387)
- Qun Li (ORCID: https://orcid.org/0000-0002-3172-8913)
- Shan-Shan Guo
- Li-Ting Liu
- Li‐Tzong Chen (ORCID: https://orcid.org/0000-0003-3250-7167)
- Kunyu Yang (ORCID: https://orcid.org/0000-0002-0478-6122)
- Shuang Wang (ORCID: https://orcid.org/0000-0002-3142-4637)
- Yi-Shing Leu (ORCID: https://orcid.org/0000-0003-1106-4766)
- Yu Wang (ORCID: https://orcid.org/0009-0009-5160-4449)
- Qiu-Yan Chen
Institutions
- Central South University (CN)
- National Yang Ming Chiao Tung University (TW)
- Kaohsiung Medical University (TW)
- Sun Yat-sen University (CN)
- National Health Research Institutes (TW)
- Mackay Memorial Hospital (TW)
- Taipei Veterans General Hospital (TW)
- Fudan University Shanghai Cancer Center (CN)
- Chris O’Brien Lifehouse (AU)
- Zhejiang Cancer Hospital (CN)
- Hunan Cancer Hospital (CN)
- Shanghai East Hospital (CN)
- Sun Yat-sen University Cancer Center (CN)
- Io Therapeutics (United States) (US)
- Regend Therapeutics (China) (CN)
- Hangzhou Cancer Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-0085
- Citations
- 1
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 1.52