Relative roles of <scp>HCN4</scp> and synaptic excitation in pyramidal neuron firing rates in a hyperactive Rheb‐<scp>mTOR</scp> condition
Overall, these experimental and computational findings advance our understanding of the mechanisms of excitability of Rheb<sup>S16H</sup> neurons, with implications for FMCD-related seizure activity due to mTOR hyperactivity.
Authors
- Angélique Bordey (ORCID: https://orcid.org/0000-0003-3496-3385)
- Youfen Xu
- Iván Soltész (ORCID: https://orcid.org/0000-0003-1493-3744)
- Stephanie A. Getz (ORCID: https://orcid.org/0000-0002-3995-2725)
- Alexandra Pierri Chatzikalymniou (ORCID: https://orcid.org/0000-0003-1678-0315)
- Dhruv Patel (ORCID: https://orcid.org/0000-0001-6486-9918)
Institutions
- Yale University (US)
- Stanford University (US)
Publication Details
- Journal
- Epilepsia
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1111/epi.18456
- Citations
- 2
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.82