Acquisition of FGFR1 and NSD3 Amplifications During the Transformation of EGFR-Mutated Lung Adenocarcinoma into Squamous Cell Carcinoma: A Case Report
Histologic transformation from adenocarcinoma to SCLC is a recognized mechanism of resistance in lung cancer. However, the transformation into squamous cell carcinoma is less common, and the associated genomic alterations remain unclear. Here, we present a case of lung adenocarcinoma harboring an EGFR (<i>EGFR</i>) mutation that transformed into squamous cell carcinoma. Although <i>EGFR</i> L858R mutation was detected throughout the transformation, genomic analyses were performed during the disease course, revealing the amplification of <i>FGFR1</i> and <i>NSD3</i>, which have recently been proposed as potential driver oncogenes in lung squamous cell carcinoma. This case report highlights the genomic alterations observed in repeatedly biopsied specimens, along with a review of the relevant literature.
Authors
- Fumimaro Ito
- Koji Okabayashi (ORCID: https://orcid.org/0000-0001-8554-1137)
- Shigenari Nukaga (ORCID: https://orcid.org/0000-0003-4136-2879)
- Kohei Shigeta (ORCID: https://orcid.org/0000-0003-1596-4200)
- Akihiko Ogata (ORCID: https://orcid.org/0000-0002-0289-3792)
- Keiko Ohgino (ORCID: https://orcid.org/0000-0002-8280-447X)
- Hideki Terai (ORCID: https://orcid.org/0000-0002-1118-1930)
- Yutaka Kurebayashi (ORCID: https://orcid.org/0000-0003-3773-0851)
- Hiroshi Nishihara (ORCID: https://orcid.org/0000-0002-5460-8703)
- Kohei Nakamura (ORCID: https://orcid.org/0000-0002-5162-7132)
- Katsuhito Kinoshita (ORCID: https://orcid.org/0009-0007-7123-6175)
- Noritaka Fukunaga (ORCID: https://orcid.org/0000-0003-2161-3319)
- Koichi Fukunaga (ORCID: https://orcid.org/0000-0001-7460-1990)
- Lisa Shigematsu
- Hatsuyo Takaoka
- Hiroyuki Yasuda (ORCID: https://orcid.org/0000-0002-7077-0655)
- Ryutaro Kawano
- Yuko Kitagawa (ORCID: https://orcid.org/0000-0002-0271-5670)
- Takahiro Fukushima
- Rui Nomura
Institutions
- Keio University (JP)
Publication Details
- Journal
- JTO Clinical and Research Reports
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1016/j.jtocrr.2025.100862
- Citations
- 1
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Takeda Science Foundation
- Japan Society for the Promotion of Science
- School of Medicine, Keio University