Bidirectional roles of nanoenzymes in enhancing GPC3-CAR T cell infiltration and cancer immunotherapy
Lenv@BSA-PtNPs provide a simple and effective strategy to enhance CAR-T cell accumulation and efficacy by ameliorating hypoxia and normalizing tumor vasculature, offering a promising approach for improving CAR-T therapy in solid tumors.
Authors
- Jianping Liao
- Aimin Huang (ORCID: https://orcid.org/0000-0002-3141-0315)
- Meiqin Gao (ORCID: https://orcid.org/0000-0002-4605-3007)
- Yu Kang T. Xu (ORCID: https://orcid.org/0000-0002-1016-0919)
- Wenwen Liu (ORCID: https://orcid.org/0000-0001-7770-2658)
- Jiahong Wang (ORCID: https://orcid.org/0000-0001-6796-1832)
- Yuan Gao (ORCID: https://orcid.org/0000-0002-0507-6499)
- Da Zhang (ORCID: https://orcid.org/0000-0002-2613-1354)
- Wenmin Zhang (ORCID: https://orcid.org/0000-0002-5090-461X)
- Yuan Wu (ORCID: https://orcid.org/0000-0003-1517-0371)
Institutions
- Fujian Medical University (CN)
- Sun Yat-sen University (CN)
- Mengchao Hepatobiliary Hospital (CN)
- Sun Yat-sen University Cancer Center (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-06-13
- DOI
- https://doi.org/10.1186/s12967-025-06636-7
- Citations
- 2
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- Fujian Provincial Finance Department
- Fujian Medical University