Abstract 1181 Identification of Novel IDO1 Inhibitors for EBV-Associated Diseases: Leveraging in Silico High-Throughput Screening and Generative AI Techniques

Epstein-Barr virus (EBV), a member of the herpesvirus family and the causative agent of infectious mononucleosis, affects over 90% of the global population. Ongoing scientific investigations continue to reveal its wide-ranging health implications. While the association between EBV and lymphoma, as well as nasopharyngeal cancer, has been well-established for several decades, its connection to gastric cancer was only identified approximately 15 years ago. Furthermore, EBV has been implicated in various autoimmune conditions, including systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis.